MON-289 Urokinase-type Plasminogen Activator May be Linked to FNDC5 Expression during Exercise
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چکیده
منابع مشابه
Urokinase type plasminogen activator receptor expression in colorectal neoplasms.
BACKGROUND The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis. AIMS To study the involvement of uPAR in colorectal carcinogenesis. METHODS The cellular expression and localisation of uPAR were investigated in colorectal adenomas and invasive carcinomas by in situ hybridisation, immunohistochemistry, and northern and western bl...
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During embryo implantation in the human trophoblast cells invade the endometrium and plasminogen activators (PA) are implicated in this tissue invasion process. Our studies on surplus embryos from patients undergoing in-vitro fertilization (IVF) treatments showed that PA activity was present in secretions of blastocysts but not embryos at the 2-4-cell stage. The secretion of this PA activity by...
متن کاملIncreased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation.
Quebec platelet disorder (QPD) is an inherited bleeding disorder associated with increased urokinase plasminogen activator (uPA) in platelets but not in plasma, intraplatelet plasmin generation, and alpha-granule protein degradation. These abnormalities led us to investigate uPA expression by QPD CD34(+) progenitors, cultured megakaryocytes, and platelets, and whether uPA was stored in QPD alph...
متن کاملExpression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing.
The urokinase-type plasminogen activator (uPA) system has been implicated in cell migration, angiogenesis, extracellular matrix synthesis and tissue remodelling. However, little is known about the role of the system in tendon healing. We used a rat Achilles tendon model to study mRNA and protein expression of uPA and its receptor (uPAR) during tendon healing using immunohistochemical, Northern ...
متن کاملUrokinase-type plasminogen activator expression is induced in the mouse mammary gland during development
The mammary gland undergoes extensive, but finely controlled tissue remodeling throughout its growth and development. During post-pubertal maturation of the ductal tree, a variety of proteinases, growth factors and integrins are expressed in a well-regulated spatial and temporal pattern (Ossowski et al., 1979; Busso et al., 1989; Robinson et al., 1991; ColemanKmacik and Rosen, 1994; Witty et al...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2019
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2019.05.1097